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Updated: Apr 24, 2026

Author Spotlight: Enhancing In Vitro Cell Culture Models with Recombinant Functionalized Spider Silk Membranes
Published on: November 1, 2024
A small molecule peptidomimetic of spider silk and webs
Krishnendu Maji1, Rajib Sarkar, Santu Bera
1Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal 741246, India. deba_h76@yahoo.com deba_h76@iiserkol.ac.in.
Abstract:
A peptidomimetic compound containing leucine, tyrosine and malonic acid self-assembles through various noncovalent interactions to form spider silk-like fibers at ambient temperature. From the high-density liquid, a liquid-solid phase transition is initiated at 20 °C and solidification occurs upon contact with air. The fiber has comprehensive mechanical strength and optical properties similar to spider silk, and can be used to mimic a natural spider web.
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