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Brush-like polycarbonates containing dopamine, cations, and PEG providing a broad-spectrum, antibacterial, and
Chuan Yang1, Xin Ding, Robert J Ono
1Institute of Bioengineering and Nanotechnology, 31 Biopolis way, The Nanos, Singapore, 138669, Singapore.
Abstract:
An antibacterial and antifouling surface is obtained by simple one-step immersion of a catheter surface with brush-like polycarbonates containing pendent adhesive dopamine, antifouling polyethylene glycol (PEG), and antibacterial cations. This coating demonstrates excellent antibacterial and antifouling activities against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria, proteins, and platelets, good stability under simulated blood-flow conditions, and no toxicity.
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