Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

721
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
721
Drug Absorption: Overview01:17

Drug Absorption: Overview

2.7K
The process of drug absorption signifies the transition of a drug from its site of administration into the plasma. This process is influenced by various factors, including the route of administration, the anatomy of the absorption site, the mechanism of absorption, gut motility, and the drug's physicochemical properties.
When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI)...
2.7K
Water and Mineral Acquisition02:34

Water and Mineral Acquisition

24.2K
Specialized tissues in plant roots have evolved to capture water, minerals, and some ions from the soil. Roots exhibit a variety of branching patterns that facilitate this process. The outermost root cells have specialized structures called root hairs that increase the root surface, thus increasing soil contact. Water can passively cross into roots, as the concentration of water in the soil is higher than that of the root tissue. Minerals, in contrast, are actively transported into root cells.
24.2K
Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

883
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
883
Drug Absorption Mechanism: Passive Membrane Transport01:23

Drug Absorption Mechanism: Passive Membrane Transport

6.8K
Passive transport is a method of drug absorption where small, lipid-soluble drugs can move across the cell membrane. This movement happens along the concentration gradient, which is a natural flow from higher to lower concentration areas. The speed at which the drug moves is directly related to its lipid–water partition coefficient. This means that the more a drug dissolves in lipids, the faster it diffuses or spreads throughout the body. It is important to note that most drugs are either...
6.8K
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

2.5K
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Skin Cancer in the Rural South: Strengthening Dermatologic Training for Frontline Primary Care.

Cureus·2026
Same author

Longer Pembrolizumab Therapy Reduces Mortality in Stage III and IV Melanoma: A TriNetX Study.

Journal of drugs in dermatology : JDD·2026
Same author

Excited Skin Syndrome (Angry Back), What Do We Know About It? A Review of the Literature.

Journal of cosmetic dermatology·2026
Same author

The Effect of Sequential Topical Application of Dermatologic Medications on Absorption: Clinical Considerations.

Skin pharmacology and physiology·2026
Same author

Eyelid dermatitis: Work-up and future diagnostic innovative solutions.

Progress in retinal and eye research·2025
Same author

Neurocosmetics are cosmetics, which mean that they could have effects only on skin.

Clinics in dermatology·2025
Same journal

Research trends on triclosan: a bibliometric analysis and comprehensive review.

Reviews on environmental health·2026
Same journal

Initiating transformative medical practices to address environmental challenges - proceedings of "Santé en 2050", the French national conference on healthcare adaptation.

Reviews on environmental health·2026
Same journal

Comparative performance analysis of physical treatment techniques for organophosphorus insecticide decontamination in aqueous systems: a systematic review.

Reviews on environmental health·2026
Same journal

Unveiling the invisible burden from cup to body: a comprehensive profiling of microplastics and nanoplastics released from tea bags.

Reviews on environmental health·2026
Same journal

Air quality and public health co-benefits of national transport policies.

Reviews on environmental health·2026
Same journal

A systematic review of radon concentrations and its lung cancer burden in Iran over two decades (2024-2000).

Reviews on environmental health·2026
See all related articles

Related Experiment Video

Updated: Apr 24, 2026

Two-Dimensional Visualization and Quantification of Labile, Inorganic Plant Nutrients and Contaminants in Soil
12:03

Two-Dimensional Visualization and Quantification of Labile, Inorganic Plant Nutrients and Contaminants in Soil

Published on: September 1, 2020

6.3K

Percutaneous absorption from soil.

Rosa Marie Andersen, Garrett Coman, Nicholas R Blickenstaff

    Reviews on Environmental Health
    |September 11, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Human skin absorption of soil contaminants varies. While generally lower than from water, factors like soil properties and compound lipophilicity influence percutaneous uptake, necessitating in vivo validation for accurate risk assessment.

    More Related Videos

    Quantification of Polybutylene Adipate Terephthalate-based Micro- and Nano-plastics from Soil Using Proton Nuclear Magnetic Resonance Spectroscopy
    05:05

    Quantification of Polybutylene Adipate Terephthalate-based Micro- and Nano-plastics from Soil Using Proton Nuclear Magnetic Resonance Spectroscopy

    Published on: June 6, 2025

    854
    Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique
    07:06

    Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

    Published on: September 28, 2022

    1.8K

    Related Experiment Videos

    Last Updated: Apr 24, 2026

    Two-Dimensional Visualization and Quantification of Labile, Inorganic Plant Nutrients and Contaminants in Soil
    12:03

    Two-Dimensional Visualization and Quantification of Labile, Inorganic Plant Nutrients and Contaminants in Soil

    Published on: September 1, 2020

    6.3K
    Quantification of Polybutylene Adipate Terephthalate-based Micro- and Nano-plastics from Soil Using Proton Nuclear Magnetic Resonance Spectroscopy
    05:05

    Quantification of Polybutylene Adipate Terephthalate-based Micro- and Nano-plastics from Soil Using Proton Nuclear Magnetic Resonance Spectroscopy

    Published on: June 6, 2025

    854
    Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique
    07:06

    Investigating Long-Distance Transport of Perfluoroalkyl Acids in Wheat via a Split-Root Exposure Technique

    Published on: September 28, 2022

    1.8K

    Area of Science:

    • Environmental Science
    • Toxicology
    • Dermatology

    Background:

    • Contaminated soils pose percutaneous exposure risks in occupational and recreational settings.
    • Chemicals in soil originate from atmospheric deposition and industrial accidents.
    • Understanding skin absorption from soil is crucial for human health risk assessment.

    Purpose of the Study:

    • To investigate the factors influencing percutaneous absorption of chemicals from soil.
    • To compare skin absorption rates from soil versus other matrices like water or acetone.
    • To evaluate the reliability of in vitro studies for human risk assessment of soil contaminants.

    Main Methods:

    • Consideration of experimental parameters: soil load, particle size, layering, and soil aging.
    • Comparison of in vitro and in vivo study designs for skin absorption.
    • Analysis of absorption data for various organic and non-organic soil contaminants.

    Main Results:

    • Skin absorption from soil is typically lower than from water/acetone.
    • Absorption of certain compounds (e.g., pentachlorophenol, chlordane, PCB 1254) from soil can be significant.
    • Lipophilic compounds (e.g., DDT, benzo[A]pyrene) and metals tend to accumulate in skin reservoirs.

    Conclusions:

    • Experimental design significantly impacts the interpretation of soil percutaneous absorption studies.
    • In vitro data alone may not be sufficient for accurate human risk assessment.
    • In vivo validation is often required to confirm the relevance of in vitro findings for risk assessment.