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Systemic infection and inflammation as trigger factors of ischemic stroke

Sukdeb Das1, Kartick Chandra Ghosh2, Satyabrata Pulai1

  • 1Department of Medicine and.

Annals of Neurosciences
|September 11, 2014
PubMed

Insights

Recent infections, particularly respiratory ones, are significant triggers for ischemic stroke, even in well-controlled patients. Early detection and treatment of infections may help reduce stroke incidence.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiovascular Medicine

Background:

  • Chronic risk factors for stroke and myocardial infarction are known, but stroke triggers require further evaluation.
  • Previous research explored the link between preceding infection/inflammation and stroke onset.

Purpose of the Study:

  • To better define stroke triggers and inform early intervention strategies.
  • To investigate the role of infections as potential stroke triggers.

Main Methods:

  • Retrospective analysis of 70 ischemic stroke patients and 80 controls.
  • Standardized questionnaires assessed recent infections (within 14 days), health status, and medical history.
  • Biochemical tests included high-sensitivity C-reactive protein (hs-CRP) and leukocyte count.

Main Results:

  • Respiratory tract infection (RTI) was more common in stroke patients (48.5%) than controls (30%).
  • Clinical and biochemical evidence (leukocytosis, elevated hs-CRP) supported infections like RTI and UTI as stroke triggers.
  • Ischemic stroke can occur suddenly after recent infection, even in patients with controlled diabetes or hypertension.

Conclusions:

  • Early treatment of febrile illnesses and adjustment of medications (antiplatelets, antibiotics) may reduce stroke incidence.
  • Further large-scale, multicenter trials are needed to confirm stroke-prone states and preventive measures.
Abstract

Keywords:
Cerebral infarctionHigh sensitivity CRPInfectionRisk factorsStroke triggers

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