Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

1.1K
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
1.1K
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

16
Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the...
16
Sex-linked Disorders01:43

Sex-linked Disorders

93.4K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
93.4K
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

9
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features...
9
General Case of Eccentric Axial Loading01:12

General Case of Eccentric Axial Loading

687
Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from symmetrical bending, which are essential for designing structures to withstand different loading conditions.
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
687
Cohesins02:20

Cohesins

4.5K
Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dry Ice in Decoverslipping Microscopic Slides: A Novel Approach.

Cureus·2026
Same author

Genomic Constellation of Foodborne Proteus Mirabilis Isolates Harboring AMR, Virulence Genes and Comparative WGS Analysis.

Current microbiology·2025
Same author

New onset diabetes mellitus in post-COVID-19 patients.

Journal of family medicine and primary care·2023
Same author

Metal-free oxidative acylation/cyclization of N-methacryloyl-2-phenylbenzoimidazole with aryl aldehydes: an easy access to benzimidazo[2,1-a]isoquinolin-6(5H)-ones.

Organic & biomolecular chemistry·2019
Same author

Organocatalytic Enantioselective Mannich Reaction: Direct Access to Chiral β-Amino Esters.

ACS omega·2019
Same author

Assessment of resistance to rice tungro disease in popular rice varieties in India by introgression of a transgene against Rice tungro bacilliform virus.

Archives of virology·2019

Related Experiment Video

Updated: Apr 24, 2026

Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
10:23

Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans

Published on: September 8, 2023

4.0K

Crouzon's Syndrome: A Case Report.

G Ravi Kumar1, M Jyothsna2, Syed Basheer Ahmed3

  • 1Associate Professor, Department of Pedodontics and Preventive Dentistry, Government Dental College and Hospital, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India.

International Journal of Clinical Pediatric Dentistry
|September 11, 2014
PubMed
Summary

Crouzon's syndrome (CS) is a rare genetic disorder affecting cranial suture development. This case report details a specific instance in an 11-year-old boy, highlighting the condition's varied presentation.

Keywords:
CraniosynostosisExophthalmosHypertelorismMidfacial hypoplasia

More Related Videos

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

442
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

12.4K

Related Experiment Videos

Last Updated: Apr 24, 2026

Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
10:23

Author Spotlight: Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans

Published on: September 8, 2023

4.0K
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
08:03

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

442
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

12.4K

Area of Science:

  • Genetics
  • Pediatric Dentistry
  • Craniofacial Surgery

Background:

  • Crouzon's syndrome (CS) is an autosomal dominant genetic disorder.
  • It is caused by mutations in the fibroblast growth factor receptor 2 (FGFR2) gene.
  • CS accounts for approximately 4.8% of craniosynostosis cases.

Observation:

  • The syndrome presents with premature closure of cranial sutures.
  • Characteristic features include cranial deformities, midface hypoplasia, hypertelorism, and proptosis.
  • Associated dental and palatal abnormalities, such as tooth crowding and cleft palate, may also occur.

Findings:

  • This report describes a case of Crouzon's syndrome in an 11-year-old boy.
  • The severity of CS can range from mild to severe, involving multiple cranial sutures.
  • The case illustrates the clinical manifestations of this rare genetic condition.

Implications:

  • Early diagnosis and management of Crouzon's syndrome are crucial for optimal outcomes.
  • Understanding the genetic basis (FGFR2 mutations) aids in diagnosis and genetic counseling.
  • Multidisciplinary care is essential for addressing the complex craniofacial and dental issues in patients with CS.