Electroacupuncture-regulated neurotrophic factor mRNA expression in the substantia nigra of Parkinson's disease rats
Shuju Wang1, Jianqiao Fang2, Jun Ma3
1Department of Acupuncture and Moxibustion, Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310005, Zhejiang Province, China ; Teaching and Research Office of Acupuncture, College of Acupuncture & Orthopedics, Hubei University of Chinese Medicine, Wuhan 430065, Hubei Province, China.
Abstract:
Acupuncture for the treatment of Parkinson's disease has a precise clinical outcome. This study investigated the effect of electroacupuncture at Fengfu (GV16) and Taichong (LR3) acupoints in rat models of Parkinson's disease induced by subcutaneous injection of rotenone into rat neck and back. Reverse transcription-PCR demonstrated that brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression was significantly increased in the substantia nigra of rat models of Parkinson's disease, and that abnormal behavior of rats was significantly improved following electroacupuncture treatment. These results indicated that electroacupuncture treatment upregulated brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor mRNA expression in the substantia nigra of rat models of Parkinson's disease. Thus, electroacupuncture may be useful in the treatment of Parkinson's disease.
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