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Microporous polysaccharide hemospheres and seroma formation after mastectomy and axillary dissection in rats
Tufan Egeli1, Ali İbrahim Sevinç1, Seymen Bora1
1Department of General Surgery, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
Objective:
Seroma is the most common complication after breast surgery. Several methods have been proposed to prevent seroma, but none of these provided a significant effect. A prolonged wound healing process is the most important cause of seroma. Microporous polysaccharide hemospheres (MPH) are used to achieve hemostasis. They may also accelerate wound healing. In this study, the effects of MPH on seroma formation were investigated.
Material And Methods:
Female Wistar rats weighing between 200 g and 250 g were used. There were eight rats in each of the control and study groups. Right breast mastectomy and axillary dissection were performed in all rats. While no application was performed after the operation in the control group, MPH was locally applied to the surgical site in the study group. Ten days after the operation, seroma fluid was aspirated and the total volume was recorded. The aspirates were analyzed and tissue samples were obtained from the surgical site.
Results:
Seroma was significantly lower in the study group (p=0.001). The mean albumin and lactate dehydrogenase levels were significantly lower in the study group (p=0.003). Pathological examination revealed that increase in fibrous tissue was significantly greater in the control group (p=0.032).
Conclusion:
MPH may reduce seroma after mastectomy.
Insights
Microporous polysaccharide hemospheres (MPH) significantly reduced seroma formation after mastectomy in a rat study. This intervention may offer a new approach to managing post-surgical complications.
Area of Science:
- Surgical oncology
- Biomaterials science
- Wound healing research
Background:
- Seroma is a frequent complication following breast surgery, impacting patient recovery.
- Current preventative methods for seroma lack significant efficacy.
- Prolonged wound healing is a key factor contributing to seroma development.
Purpose of the Study:
- To investigate the efficacy of microporous polysaccharide hemospheres (MPH) in preventing seroma formation after mastectomy.
- To evaluate the impact of MPH on wound healing processes relevant to seroma development.
Main Methods:
- A rat model involving right breast mastectomy and axillary dissection was utilized.
- Microporous polysaccharide hemospheres (MPH) were applied to the surgical site in the study group; the control group received no application.
- Seroma fluid volume, albumin, and lactate dehydrogenase levels were measured post-operatively. Pathological tissue analysis was also performed.
Main Results:
- A statistically significant reduction in seroma volume was observed in the MPH-treated group (p=0.001).
- Mean albumin and lactate dehydrogenase levels were significantly lower in the study group (p=0.003).
- Increased fibrous tissue, indicative of healing, was significantly greater in the control group (p=0.032).
Conclusions:
- Microporous polysaccharide hemospheres (MPH) demonstrate potential in reducing seroma formation subsequent to mastectomy.
- MPH may positively influence wound healing, thereby mitigating seroma development.
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