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Related Experiment Video

Updated: Jan 15, 2026

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

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Specific immunotherapy for allergic rhinitis in children.

Chengshuo Wang1, Luo Zhang

  • 1aDepartment of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University bBeijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, People's Republic of China.

Current Opinion in Otolaryngology & Head and Neck Surgery
|September 11, 2014
PubMed
Summary

Allergen-specific immunotherapy (SIT) effectively treats allergic rhinitis in children. While subcutaneous immunotherapy shows slightly better results, sublingual immunotherapy (SLIT) offers a safer, needle-free option suitable for pediatric patients.

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[Treatment of allergic rhinitis in the biologics era].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery·2026
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Area of Science:

  • Pediatric Allergy and Immunology
  • Immunotherapy Research
  • Inflammatory Diseases

Background:

  • Allergic rhinitis affects 20-40% of children globally.
  • Allergen-specific immunotherapy (SIT) is a recognized treatment.
  • Advances in pediatric SIT are under review.

Purpose of the Study:

  • To review recent advancements in SIT for children.
  • To highlight current treatment modalities and future directions.
  • To discuss the efficacy and safety of different SIT approaches.

Main Methods:

  • Review of current clinical practices in immunotherapy.
  • Analysis of meta-analyses and comparative studies.
  • Exploration of immunological mechanisms involved in SIT.

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Main Results:

  • Subcutaneous immunotherapy (SCIT) trends towards greater efficacy than sublingual immunotherapy (SLIT).
  • SLIT demonstrates a superior safety profile and is well-suited for children due to needle-free administration.
  • T regulatory cells, particularly Tr1 cells, are implicated in SIT's mechanism of action.

Conclusions:

  • Both SCIT and SLIT are effective, but safer and more effective SIT methods are required.
  • Novel approaches like omalizumab pretreatment, recombinant allergens, and alternative administration routes are promising.
  • Continued research is essential to optimize SIT for pediatric allergic rhinitis.