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Advanced research on anti-tumor effects of amygdalin
1Department of Nursing, College of Nursing, Tianjin Medical University, Tianjin, China.
Abstract:
Malignant tumors are the major disease that cause serious damage to human health, and have been listed as the premier diseases which seriously threatened human health by World Health Organization (WHO). In recent years the development of antitumor drugs has been gradually transformed from cytotoxic drugs to improving the selectivity of drugs, overcoming multidrug resistance, development of new targeted drugs and low toxicity with high specificity drugs. Amygdalin is a natural product that owns antitumor activity, less side effects, widely sourced and relatively low priced. All these features make the amygdalin a promising antitumor drugs, if combined with conditional chemotherapy drugs, which can produce synergistic effect. In this paper, we summarized the pharmacological activity, toxicity and antitumor activity of amygdalin, mainly focused on the advanced research of amygdalin on its antitumor effects in recent years, providing new insights for the development of new anticancer drugs, new targets searching and natural antitumor mechanism investigations.
Insights
Amygdalin, a natural compound, shows promise as an anticancer drug due to its antitumor activity and low toxicity. Further research explores its potential synergistic effects with chemotherapy for improved cancer treatment strategies.
Area of Science:
- Pharmacology
- Natural Products Chemistry
- Oncology
Background:
- Malignant tumors pose a significant global health threat, prompting a shift towards targeted, low-toxicity anticancer therapies.
- Traditional cytotoxic chemotherapy faces challenges including drug resistance and severe side effects.
- Natural products are increasingly investigated for their therapeutic potential in cancer treatment.
Purpose of the Study:
- To review the pharmacological activity, toxicity, and antitumor effects of amygdalin.
- To highlight recent advancements in amygdalin's anticancer research.
- To explore amygdalin's potential as a component of novel anticancer drug development.
Main Methods:
- Literature review of pharmacological and toxicological studies on amygdalin.
- Analysis of recent research on amygdalin's antitumor mechanisms and efficacy.
- Synthesis of findings related to amygdalin's potential synergistic effects with chemotherapy.
Main Results:
- Amygdalin exhibits notable antitumor activity with a favorable safety profile.
- The compound is widely available and cost-effective.
- Amygdalin demonstrates potential for synergistic effects when combined with chemotherapy agents.
Conclusions:
- Amygdalin is a promising natural product for anticancer drug development.
- Its low toxicity and potential for synergy warrant further investigation.
- Amygdalin research offers insights into natural antitumor mechanisms and novel therapeutic targets.
