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Anthralin/dithranol in dermatology.

Virendra N Sehgal1, Prashant Verma, Ananta Khurana

  • 1Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati, Delhi Department of Dermatology and STD, University College of Medical Sciences, and Associated Guru Teg Bahadur Hospital, Shahdara, Delhi, India.

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Summary
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Anthralin, a century-old psoriasis treatment, is effective and safe with no systemic side effects. Despite causing skin irritation and discoloration, its pharmacology warrants revisiting for current dermatological applications.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Organic Chemistry

Background:

  • Anthralin (1,8-dihydroxy-9anthrone, dithranol) synthesized over a century ago from chrysarobin.
  • Known drawbacks include skin irritation and discoloration.
  • These properties spurred research into its pharmacology and mode of action.

Purpose of the Study:

  • To revisit and highlight the pharmacology, mode of action, and indications of Anthralin.
  • To assess its suitability for current dermatological use.
  • To emphasize its safety profile compared to other therapies.

Main Methods:

  • Literature review of Anthralin's historical and current research.
  • Analysis of pharmacological data and clinical outcomes.
  • Comparison of Anthralin's efficacy and side effect profile with existing treatments.

Main Results:

  • Anthralin demonstrates effectiveness in treating dermatoses.
  • It is characterized by a lack of systemic side effects.
  • Adverse effects are primarily localized skin irritation and discoloration.

Conclusions:

  • Anthralin remains a viable, effective, and safe topical treatment for various skin conditions.
  • Its favorable safety profile warrants consideration in modern dermatological practice.
  • Further investigation into optimizing Anthralin therapy is recommended.