Molecular Epidemiology of Pasteurella multocida Circulating in India by Multilocus Sequence Typing
L N Sarangi1, P Thomas1, S K Gupta1
1Division of Veterinary Bacteriology and Mycology, Indian Veterinary Research Institute, Izzatnagar, Bareilly, India.
Transboundary and Emerging Diseases
|September 12, 2014
Summary
Multilocus sequence typing (MLST) reveals diverse Pasteurella multocida strains in India. New sequence types (STs) were identified, suggesting global strain circulation and informing haemorrhagic septicaemia control strategies.
Area of Science:
- Bacteriology
- Epidemiology
- Population Genetics
Background:
- Multilocus sequence typing (MLST) is crucial for bacterial pathogen epidemiology and population structure analysis.
- Understanding Pasteurella multocida diversity in India is essential for disease control.
Purpose of the Study:
- To investigate the genetic diversity of Pasteurella multocida isolates circulating within India.
- To identify novel sequence types (STs) and understand their distribution.
Main Methods:
- Utilized multilocus sequence typing (MLST) to analyze Pasteurella multocida isolates.
- Characterized genetic variation and identified distinct sequence types (STs).
Main Results:
- Identified ten distinct sequence types (STs) across various animal hosts in India.
- Discovered four novel STs: ST 277, ST 280, ST 281, and ST 282.
- Observed that most identified STs have been previously reported globally, indicating transboundary strain spread.
Conclusions:
- The study provides novel epidemiological insights into Pasteurella multocida circulation in India.
- The widespread presence of ST 122 in cattle, goats, mithun, and pigs suggests its importance in haemorrhagic septicaemia.
- Inclusion of ST 122 in vaccination policies could enhance haemorrhagic septicaemia control in India.
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