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Updated: Apr 24, 2026

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
Published on: July 28, 2023
Retinal degeneration in animal models with a defective visual cycle
Akiko Maeda1, Krzysztof Palczewski2
1Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 ; Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106.
Abstract:
Continuous generation of visual chromophore through the visual (retinoid) cycle is essential to maintain eyesight and retinal heath. Impairments in this cycle and related pathways adversely affect vision. In this review, we summarize the chemical reactions of vitamin A metabolites involved in the retinoid cycle and describe animal models of associated human diseases. Development of potential therapies for retinal disorders in these animal models is also introduced.

