Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glycocalyx and its Functions01:14

Glycocalyx and its Functions

9.1K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Posttranslational modifications remodel proteome-wide ligandability.

Nature chemical biology·2026
Same author

Human Sulfatases Use Dual Mechanisms to Control Growth Factor-Heparan Sulfate Interactions.

ACS chemical biology·2026
Same author

Posttranslational modifications remodel proteome-wide ligandability.

Nature chemical biology·2026
Same author

Recent advances in mapping protein networks regulated by post-translational modifications via proximity tagging.

Current opinion in chemical biology·2026
Same author

Galectin-3-Induced Glycan Lattices as Biophysical Modulators of Membrane Phase Behavior in Live Cells.

ACS chemical biology·2026
Same author

Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells.

Nature chemical biology·2026

Related Experiment Video

Updated: Apr 24, 2026

Identifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan
11:39

Identifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan

Published on: September 7, 2019

4.8K

Priming the cellular glycocalyx for neural development.

Mia L Huang1, Kamil Godula

  • 1Department of Chemistry and Biochemistry, University of California , San Diego, California 92093-0358, United States.

ACS Chemical Neuroscience
|September 12, 2014
PubMed
Summary
This summary is machine-generated.

Scientists are developing new tools to engineer cell surfaces with specific glycans for nervous system therapies. This approach aims to unlock the therapeutic potential of glycans for neuroregeneration.

More Related Videos

Cultivation of Human Neural Progenitor Cells in a 3-dimensional Self-assembling Peptide Hydrogel
11:01

Cultivation of Human Neural Progenitor Cells in a 3-dimensional Self-assembling Peptide Hydrogel

Published on: January 11, 2012

15.9K
Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

13.8K

Related Experiment Videos

Last Updated: Apr 24, 2026

Identifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan
11:39

Identifying Cell Surface Markers of Primary Neural Stem and Progenitor Cells by Metabolic Labeling of Sialoglycan

Published on: September 7, 2019

4.8K
Cultivation of Human Neural Progenitor Cells in a 3-dimensional Self-assembling Peptide Hydrogel
11:01

Cultivation of Human Neural Progenitor Cells in a 3-dimensional Self-assembling Peptide Hydrogel

Published on: January 11, 2012

15.9K
Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

13.8K

Area of Science:

  • Neuroscience
  • Glycobiology
  • Biomedical Engineering

Background:

  • Glycans play crucial roles in nervous system development and function.
  • Limited tools for controlling cell surface glycan presentation hinder research and therapeutic applications.
  • The complexity of the glycome presents significant challenges for biomedical exploration.

Purpose of the Study:

  • To summarize challenges in glycan research.
  • To introduce cell surface engineering with synthetic glycoconjugate mimetics.
  • To explore applications in stem cell-based neuroregenerative therapies.

Main Methods:

  • Reviewing challenges in glycan structure presentation.
  • Highlighting synthetic nanoscale mimetics of glycoconjugates.
  • Focusing on cell surface engineering strategies.

Main Results:

  • Identified challenges in studying and manipulating cell surface glycans.
  • Proposed synthetic mimetics as a tool for glycan presentation.
  • Outlined potential for advancing neuroregeneration.

Conclusions:

  • Cell surface engineering with synthetic glycans offers a promising avenue.
  • This approach can overcome current limitations in glycan research.
  • Potential to significantly advance stem cell-based neuroregenerative therapies.