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Related Experiment Video

Updated: Jan 25, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Treating tuberculosis in solid organ transplant recipients.

Hsin-Yun Sun1

  • 1Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Current Opinion in Infectious Diseases
|September 12, 2014
PubMed
Summary
This summary is machine-generated.

Active tuberculosis (TB) management in solid organ transplant (SOT) recipients is feasible. Rifampin-based regimens are effective for TB treatment in SOT patients, with careful immunosuppressant monitoring to prevent rejection.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Transplant Medicine

Background:

  • Tuberculosis (TB) poses significant risks for solid organ transplant (SOT) recipients.
  • Active TB is not an absolute contraindication for SOT.

Purpose of the Study:

  • To review current findings on managing active TB in SOT recipients.
  • To assess the safety and efficacy of TB treatment in this population.

Main Methods:

  • Literature review of recent studies on TB management in SOT recipients.
  • Analysis of outcomes related to TB treatment and immunosuppression.

Main Results:

  • Rifampin-based TB regimens can be used in SOT recipients.
  • Close monitoring of immunosuppressant levels is crucial during rifampin therapy.
  • TB-associated immune reconstitution syndrome (IRIS) affects 14% of SOT recipients, with risk factors including liver transplant and CMV infection.

Conclusions:

  • SOT is possible for patients with active TB.
  • Rifampin-based TB treatment is a viable option for SOT recipients.
  • Physicians should recognize IRIS in SOT patients to ensure appropriate management.