Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

945
α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
945
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

1.1K
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
1.1K
Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

1.3K
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
1.3K
Oral Hypoglycemic Agents: Glinides01:06

Oral Hypoglycemic Agents: Glinides

1.0K
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
1.0K
Glucose Transporters01:27

Glucose Transporters

15.1K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
15.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ru-Based NSAIDs as Potential Anticancer Therapeutics.

Molecules (Basel, Switzerland)·2026
Same author

New Compounds with Enhanced Biological Activity Through the Strategic Introduction of Silylated Groups into Hydroxystearic Acids.

Molecules (Basel, Switzerland)·2025
Same author

Unpredictable Dynamic Behaviour of Ruthenium Chelate Pyrrole Derivatives.

Molecules (Basel, Switzerland)·2024
Same author

Aryl diazonium salts and benzene derivatives bearing two electron-donor substituents: chemical and mechanistic behaviours.

RSC advances·2024
Same author

Interactions between Damaged Hair Keratin and Juglone as a Possible Restoring Agent: A Vibrational and Scanning Electron Microscopy Study.

Molecules (Basel, Switzerland)·2024
Same author

Suberoylanilide Hydroxamic Acid Analogs with Heteroaryl Amide Group and Different Chain Length: Synthesis and Effect on Histone Deacetylase.

Molecules (Basel, Switzerland)·2024

Related Experiment Video

Updated: Apr 24, 2026

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
08:09

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

23.1K

Interaction between gliadins and anthocyan derivatives.

Palmira Mazzaracchio1, Silvia Tozzi1, Carla Boga2

  • 1Department of Business Science - Area Technology and Resource Valorization, Alma Mater Studiorum - University of Bologna, Piazza Scaravilli 2, 40126 Bologna, Italy.

Food Chemistry
|September 13, 2014
PubMed
Summary

This study shows that anthocyanins and anthocyanidins interact with gliadins in the stomach. These anthocyan-gliadin complexes are soluble in acidic conditions, offering insights into food interactions and potential health benefits.

Keywords:
AnthocyaninsGliadinsInteractionSpectroscopy

More Related Videos

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria
06:38

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria

Published on: February 28, 2025

763
Visualizing Lignification Dynamics in Plants with Click Chemistry: Dual Labeling is BLISS!
10:40

Visualizing Lignification Dynamics in Plants with Click Chemistry: Dual Labeling is BLISS!

Published on: January 26, 2018

14.3K

Related Experiment Videos

Last Updated: Apr 24, 2026

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics
08:09

Annotation of Plant Gene Function via Combined Genomics, Metabolomics and Informatics

Published on: June 17, 2012

23.1K
Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria
06:38

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria

Published on: February 28, 2025

763
Visualizing Lignification Dynamics in Plants with Click Chemistry: Dual Labeling is BLISS!
10:40

Visualizing Lignification Dynamics in Plants with Click Chemistry: Dual Labeling is BLISS!

Published on: January 26, 2018

14.3K

Area of Science:

  • Food chemistry and nutrition
  • Biochemistry of plant compounds
  • Protein-ligand interactions

Background:

  • Anthocyanins and anthocyanidins are plant pigments with potential health benefits.
  • Gliadins are gluten proteins found in wheat.
  • Understanding their interaction is crucial for food processing and digestion.

Purpose of the Study:

  • To investigate the molecular interactions between gliadins and various anthocyanins/anthocyanidins.
  • To determine the binding mode and solubility of these complexes under acidic conditions simulating the stomach.

Main Methods:

  • Nuclear Magnetic Resonance (NMR) spectroscopy
  • Fourier-Transform Infrared (FT-IR) spectroscopy
  • UV-Visible (UV-Vis) spectroscopy

Main Results:

  • Spectroscopic data indicate a general molecular interaction between anthocyanins/anthocyanidins and gliadin polypeptide chains.
  • Hydrogen bonding may also contribute to the interaction.
  • The resulting anthocyan-gliadin complexes exhibit high solubility in acidic conditions.

Conclusions:

  • This research elucidates the binding mechanisms between plant pigments and gluten proteins.
  • The findings provide novel insights into anthocyanin-protein interactions relevant to food digestion and human health.