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Updated: Apr 24, 2026

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Silaproline helical mimetics selectively form an all-trans PPII helix

Charlotte Martin1, Baptiste Legrand, Aurélien Lebrun

  • 1Institut des Biomolécules Max Mousseron, UMR 5247, CNRS-UM2-UM1-ENSCM, Place Eugène Bataillon, CC1703, 34095 Montpellier (France).

Chemistry (Weinheim an Der Bergstrasse, Germany)
|September 13, 2014
PubMed
Summary

Researchers synthesized silaproline oligomers, finding they form a stable polyproline II helix (PPII). This discovery offers new lipophilic PPII-like structures for peptide and protein research.

Keywords:
NMR spectroscopyhelixmolecular modelingpeptidomimeticssilaproline

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