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Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters

Chin-Lin Hsu1, Yuan-Yen Chang2, Chih-Hsien Chiu3

  • 1School of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan; Department of Nutrition, Chung Shan Medical University Hospital, Taichung 402, Taiwan.

Food Chemistry
|September 13, 2014
PubMed

Insights

Deep-seawater (DSW) drinking water helped reduce cardiovascular risks in hamsters fed a high-fat/cholesterol diet. DSW intake lowered harmful cholesterol and improved antioxidant capacity, suggesting cardiovascular protection.

Area of Science:

  • Biochemistry
  • Cardiovascular Science
  • Nutritional Science

Background:

  • High-fat/cholesterol diets induce cardiovascular disorders.
  • Deep-seawater (DSW) is a potential source of minerals and bioactive compounds.
  • Assessing DSW's impact on diet-induced cardiovascular issues is important.

Purpose of the Study:

  • To evaluate the cardiovascular protective effects of DSW drinking water.
  • To investigate DSW's influence on lipid metabolism and oxidative stress markers.
  • To examine DSW's effect on gene expression related to cholesterol regulation.

Main Methods:

  • Hamsters were fed a high-fat/cholesterol diet for 6 weeks.
  • Drinking solutions included normal distilled water (NDW) and DSW at varying hardness levels (DSW300, DSW900, DSW1500).
  • Measurements included body weight, heart rate, blood pressure, serum lipids, oxidative stress markers, fecal outputs, and hepatic gene expression.

Main Results:

  • DSW drinking water did not affect body weight, heart rate, or blood pressure.
  • Serum total cholesterol, triacylglycerol, atherogenic index, and malondialdehyde levels were reduced in DSW groups.
  • Increased serum antioxidant capacity and fecal lipid/bile acid outputs were observed in DSW groups.
  • Hepatic LDL receptor and CYP7A1 gene expressions were upregulated by DSW.

Conclusions:

  • DSW drinking water demonstrates cardiovascular protective benefits.
  • DSW helps attenuate high-fat/cholesterol-diet-induced cardiovascular disorders.
  • DSW positively influences lipid metabolism and cholesterol regulation pathways.

Keywords:
CYP7A1Cardiovascular protectionDeep seawaterHamsterLDL receptorSerum lipid peroxidationSerum lipids

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