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Updated: Apr 24, 2026

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Published on: January 24, 2018

Keratoconus: tissue engineering and biomaterials.

Dimitrios Karamichos¹, Jesper Hjortdal²

¹Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L. Young Blvd, DMEI PA-409, Oklahoma City, OK 73104, USA. dimitrios-karamichos@ouhsc.edu.

Journal of Functional Biomaterials

|September 13, 2014

Summary

This summary is machine-generated.

Keratoconus (KC) is a progressive corneal disease affecting vision. Current treatments are limited, but biomaterials show promise for managing KC progression and preventing vision loss.

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Area of Science:

Ophthalmology
Biomaterials Science
Corneal Disorders

Background:

Keratoconus (KC) is a bilateral, asymmetric corneal disorder characterized by progressive thinning, steepening, and scarring.
Its prevalence is approximately 1 in 2000 worldwide, with higher incidence in specific populations.
The exact cause of KC remains unknown, despite investigations into genetic, cellular, and mechanical factors.

Purpose of the Study:

To review current treatments for keratoconus.
To explore the potential of biomaterials in managing KC progression.
To address the challenge of early-stage treatment and vision impairment prevention.

Main Methods:

Literature review of current keratoconus treatments.
Analysis of existing research on biomaterials for ocular applications.
Discussion of tissue engineering techniques relevant to corneal disorders.

Main Results:

Keratoconus progression varies individually, often continuing into the third or fourth decade of life.
Current treatment options for early-stage KC and vision impairment prevention are limited.
Advancements in tissue engineering and biomaterials offer potential therapeutic strategies.

Conclusions:

Biomaterials represent a promising avenue for developing novel treatments to arrest keratoconus progression.
Further research into biomaterial applications is crucial for improving patient quality of life and preventing vision loss associated with KC.