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Quantitative Analyses of all Influenza Type A Viral Hemagglutinins and Neuraminidases using Universal Antibodies in Simple Slot Blot Assays
Published on: April 4, 2011
Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method
Jan P Radomski1, Piotr P Słonimski2, Włodzimierz Zagórski-Ostoja3
1Interdisciplinary Center for Mathematical and Computational Modeling, Warsaw University, Warsaw, Poland and Institute of Biotechnology and Antibiotics, Warsaw, Poland.
Abstract:
Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we consider application of the ISSCOR-PCA method for analyses of large sets of homologous genes to be a worthwhile addition to a toolbox of genomics--allowing for a rapid diagnostics of trends, and ultimately even aiding an early warning of newly emerging epidemiological threats.
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