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Randomized controlled trial of testosterone in myotonic dystrophy
R C Griggs1, S Pandya, J M Florence
1Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642.
Neurology
|February 1, 1989
Summary
Testosterone treatment increased muscle mass in men with myotonic dystrophy but did not improve muscle strength. This 12-month trial found no strength benefits despite anabolic effects.
Area of Science:
- Neurology
- Endocrinology
- Rehabilitation Medicine
Background:
- Myotonic dystrophy is a genetic disorder characterized by muscle wasting and weakness.
- Testosterone is known to have anabolic effects, suggesting potential benefits for muscle mass and strength.
Purpose of the Study:
- To investigate the efficacy of testosterone enanthate in improving muscle strength and mass in men with myotonic dystrophy.
Main Methods:
- A 12-month, randomized, double-blind, placebo-controlled trial involving 40 men with myotonic dystrophy.
- Evaluations included manual muscle testing, quantitative myometry, pulmonary function, and functional assessments.
- Muscle mass was assessed via creatinine excretion and lean body mass (40K method).
Main Results:
- Testosterone enanthate significantly increased testosterone levels and muscle mass.
- No significant improvements were observed in any measure of muscle strength or pulmonary function.
- Lean body mass also showed a significant increase.
Conclusions:
- Testosterone therapy does not enhance muscle strength in individuals with myotonic dystrophy.
- Despite increasing muscle mass, testosterone does not translate to functional strength gains in this population.