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Predictors for mortality following acute pancreatitis in children

Qiang Guo1, Mao Li, Yang Chen

  • 1Hepato-Bilio-Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.

Pediatric Surgery International
|September 14, 2014
PubMed

Insights

Pediatric acute pancreatitis has a low mortality rate, but early organ failure, SIRS, MOF, infected necrosis, and idiopathic causes increase the risk of death in children.

Area of Science:

  • Pediatric Gastroenterology
  • Critical Care Medicine

Background:

  • Acute pancreatitis in children is a significant clinical concern.
  • Etiology and clinical outcomes of pediatric pancreatitis are documented, but risk factors for mortality remain under-explored.

Purpose of the Study:

  • To identify independent predictors of death in children diagnosed with acute pancreatitis.
  • To analyze risk factors associated with mortality in pediatric acute pancreatitis cases.

Main Methods:

  • Retrospective review of medical records for children (0-18 years) with acute pancreatitis from 2002-2012.
  • Multivariate logistic regression analysis to determine independent predictors of mortality.

Main Results:

  • Common etiologies included biliary diseases (23%), medications (20%), idiopathic (19%), and trauma (11%).
  • The overall mortality rate was 5%, with a mean hospital stay of 13 days.
  • Independent risk factors for death included Systemic Inflammatory Response Syndrome (SIRS) in the first week (OR=2.12), organ failure within 3 days (OR=8.0), Multiple Organ Failure (MOF) in the first week (OR=9.4), infected necrosis (OR=1.28), and idiopathic cause (OR=17.3).

Conclusions:

  • The mortality and complication rates for pediatric acute pancreatitis are relatively low.
  • Children experiencing SIRS, early organ failure, MOF, infected necrosis, or having an idiopathic cause require vigilant evaluation due to elevated mortality risk.
Abstract

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