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Updated: Apr 24, 2026

Production of Replication-Defective Retrovirus by Transient Transfection of 293T cells
Published on: December 4, 2007
Recent developments linking retroviruses to human breast cancer: infectious agent, enemy within or both?
Brian Salmons1, James S Lawson2, Walter H Günzburg3
1Austrianova, 20 Biopolis Way, 05-518 Centros, Republic of Singapore 138668.
Abstract:
Evidence is accumulating that one or more beta-retrovirus is associated with human breast cancer. Retroviruses can exist as an infectious (exogenous) virus or as a part of the genetic information of cells due to germline integration (endogenous). An exogenous virus with a genome that is highly homologous to mouse mammary tumour virus is gaining acceptance as possibly being associated with human breast cancer, and recently furnished evidence is discussed in this article, as is the evidence for involvement of an endogenous human beta-retrovirus, HERV-K. Modes of interaction are also reviewed and linkages to the APOBEC3 family are suggested.
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