Related Experiment Video
Updated: Apr 24, 2026
04:14
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
Published on: April 16, 2019
13.0K
Alcoholic and non-alcoholic steatohepatitis
Manuela G Neuman1, Samuel W French2, Barbara A French2
1In Vitro Drug Safety and Biotechnology, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Experimental and Molecular Pathology
|September 15, 2014
Summary
Alcoholic liver disease (ALD) and non-alcoholic steatohepatitis (NASH) share toxic roles and histological stages. Research explores genetic factors, immune responses, and diagnostic markers for these conditions.
Area of Science:
- Hepatology
- Alcoholism Research
- Translational Medicine
Background:
- Alcoholic liver disease (ALD) and non-alcoholic steatohepatitis (NASH) are significant health concerns.
- ALD is characterized by simple steatosis, alcoholic steatohepatitis (ASH), and advanced fibrosis or cirrhosis.
- Both conditions involve complex pathogenetic mechanisms including genetic predispositions and immune responses.
Purpose of the Study:
- To review and integrate pre-clinical, translational, and clinical research on ALD and NASH.
- To elucidate the key toxic role of alcohol in ALD pathogenesis.
- To identify diagnostic markers and factors influencing disease severity in ASH and NASH.
Main Methods:
- Comprehensive literature search on alcoholic liver disease and non-alcoholic steatohepatitis.
- Analysis of clinical and experimental evidence characterizing ALD and NASH.
- Review of histological findings from liver biopsies, including stages and cellular alterations.
Main Results:
- Strong evidence confirms alcohol's critical role in ALD pathogenesis.
- Histological stages of ALD include steatosis, ASH, and cirrhosis, with specific cellular changes noted.
- Genetic polymorphisms (e.g., CYP2E1) and immune responses influence ASH and NASH severity.
Conclusions:
- ALD and NASH share overlapping features and pathogenetic pathways.
- Further research is needed to develop diagnostic markers and understand genetic and immune influences.
- Integrative research on alcohol-induced liver damage aims to advance understanding and treatment strategies.
Keywords:
Alcoholic hepatitisAlcoholic liver diseaseCYP2E1HangoverHepatocarcinogenesisHuman immunodeficiency virusImmunohistochemistryLaboratory markersMallory–Denk bodiesMethylationMicronutrientsMitochondrionNonalcoholic steatohepatitisViral hepatitisMore Related Videos
08:35A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
Published on: May 18, 2021
6.8K
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
1.9K
Related Concept Videos
01:23Cirrhosis I: Introduction
23
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
23
01:25Hepatitis
74
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
74
01:26Diseases of the Liver and Gallbladder
2.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.0K
01:21Chronic Pancreatitis II: Pathophysiology
21
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
21
01:24Cirrhosis II: Pathophysiology
26
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to...
26
01:28Viral Hepatitis I: Introduction
17
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
17