The plasma-rich in growth factor as a suitable matrix in regenerative endodontics: a case series

The aim of this report is to describe the positive effect of plasma-rich in growth factor (PRGF) on pulp regeneration and apex formation in cases with necrotic pulps and open apices. After access cavity preparation and cleaning of the canal, triple antibiotic paste was inserted into the canals for the purpose of disinfection. After two weeks, apical bleeding was mechanically created by insertion of a #80 file through the apex. PRGF obtained from the patient was centrifuged and injected into the canals up to the level of the cementoenamel junction; the teeth were restored temporarily. The patients returned for review two weeks later. If there was absence of pain, swelling, fistula or any other complication, the teeth were sealed with MTA and composite. At 22 months follow-up, complete apex closure in two teeth and apical closure and continued increase of dentinal wall thickness in two other cases were evident.