Atrial natriuretic factor (ANF): a preliminary report of cervical heart transplant model for study

The allograft canine heart transplanted to the neck of a recipient provides a useful model for direct measurement of atrionatriuretic factor (ANF) in the single inflow artery and the single outflow vein (pulmonary artery). The normal peripheral blood levels of ANF in the dog ranged from 25-77 pg/ml, whereas the post-transplant level in transplant outflow blood was 2262 pg/ml 30 minutes after transplant resuscitation. The cervical heart transplant model is applicable to a variety of ANF investigations.