Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

947
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
947

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Cardiac syndrome X and insulin resistance].

Zhonghua nei ke za zhi·2002
Same author

[Value of P-glycoprotein and glutathione S-transferase-pi as chemo-resistant indicators in ovarian cancers].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2002
Same author

[Current status of pain relief with Chinese herbal drugs in patients with cancer].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2002
Same author

[Investigation of urinary interleukin-6 level in chronic renal failure patients and the influence of Rheum palmatum in treating it].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2002
Same author

Accelerating flap maturation by vascular endothelium growth factorin a rat tube flap model.

British journal of plastic surgery·2002
Same author

[Pulmonary embolism due to deep venous thrombosis of extremities].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2002

Related Experiment Video

Updated: Apr 23, 2026

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

15.8K

Partial least squares based gene expression analysis in posttraumatic stress disorder.

K Dong1, F Zhang, W Zhu

  • 1Department of Psychology, Wuxi Mental Health Center of Nanjing Medical University, Wuxi, China. kunlundong2013@gmail.com.

European Review for Medical and Pharmacological Sciences
|September 16, 2014
PubMed
Summary

This study used partial least squares (PLS) analysis to identify gene expression signatures in posttraumatic stress disorder (PTSD). Findings reveal dysregulated immune, endocrine, and nervous pathways, offering insights into PTSD pathogenesis.

More Related Videos

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

18.3K
Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury
09:29

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Published on: September 11, 2017

10.6K

Related Experiment Videos

Last Updated: Apr 23, 2026

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

15.8K
Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
08:29

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

18.3K
Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury
09:29

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Published on: September 11, 2017

10.6K

Area of Science:

  • Genomics
  • Neuroscience
  • Psychiatry

Background:

  • Posttraumatic stress disorder (PTSD) is a psychological response to trauma.
  • Gene expression analysis offers insights into PTSD pathogenesis.
  • Previous studies often overlooked array-specific factors.

Purpose of the Study:

  • Investigate PTSD mechanisms using Partial Least Squares (PLS) analysis.
  • Identify gene expression signatures associated with PTSD.
  • Explore novel therapeutic targets for PTSD.

Main Methods:

  • Utilized gene expression profile data from the GEO database.
  • Analyzed data from 17 chronic PTSD patients and 16 trauma-recovered controls.
  • Applied Partial Least Squares (PLS) analysis for gene expression profiling.

Main Results:

  • Identified 230 down-regulated and 335 up-regulated genes in PTSD patients.
  • Detected significant dysregulation in immune, endocrine, and nervous system pathways.
  • Highlighted PRKCA, TP53, EP300, and CALM1 as potential key genes in PTSD pathogenesis.

Conclusions:

  • The study identified novel gene expression signatures in PTSD.
  • Findings provide theoretical support for future therapeutic interventions.
  • Highlights the role of immune, endocrine, and nervous pathways in PTSD.