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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma I: Introduction01:28

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Signs of Puberty01:27

Signs of Puberty

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Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
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Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

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Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Related Experiment Video

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Murine Model of Allergen Induced Asthma
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Early risk factors for pubertal asthma.

V Hovland1, A Riiser, P Mowinckel

  • 1Department of Paediatrics, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|September 16, 2014
PubMed
Summary

Early airway obstruction, parental rhinitis, being firstborn, and family stress are key early risk factors for adolescent asthma. These findings help identify children at risk for developing asthma later in life.

Keywords:
adolescenceallergic comorbidityasthmabirth cohortprospectivepubertalrisk factorsstress

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Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Epidemiology

Background:

  • Childhood asthma risk factors are established, but adolescent asthma predictors are less understood.
  • This study investigates early life factors (before age 2) associated with pubertal asthma.
  • Phenotypes of pubertal asthma, considering allergic comorbidities, were also examined.

Purpose of the Study:

  • To identify early life risk factors for asthma developing during puberty (ages 10-16).
  • To analyze risk factors for specific pubertal asthma phenotypes, including those with allergic comorbidities like atopic dermatitis and allergic rhinitis.

Main Methods:

  • A prospective birth cohort of 550 adolescents ('Environment and Childhood Asthma' study) was analyzed.
  • Participants were categorized based on early recurrent bronchial obstruction (rBO), childhood asthma, and pubertal asthma status (incident or remission).
  • Weighted logistic regression analyzed 23 early risk factors for various asthma phenotypes.

Main Results:

  • Increased pubertal asthma risk was linked to higher airway obstruction severity, parental rhinitis, being firstborn, and perinatal familial stress.
  • Asthma remission was associated with obstruction severity, respiratory infections, and inversely with prolonged breastfeeding.
  • Asthma with allergic diseases showed a strong link to obstruction severity; specific comorbidities were associated with factors like parental history and socioeconomic status.

Conclusions:

  • Early life airway obstruction, parental rhinitis, being the firstborn child, and perinatal familial stress are significant risk factors for pubertal asthma.
  • These factors can inform early identification and potential prevention strategies for adolescent asthma.
  • Understanding these early predictors is crucial for managing asthma phenotypes in adolescence.