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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

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Published on: February 8, 2017

Colloidal caterpillars for cargo transportation.

Yuji Sasaki¹, Yoshinori Takikawa, V S R Jampani

¹Division of Applied Physics, Faculty of Engineering, Hokkaido University, North 13 West 8, Kita-ku, Sapporo, Hokkaido 060-8628, Japan. orihara@eng.hokudai.ac.jp.

|September 16, 2014

Summary

This summary is machine-generated.

We demonstrate tunable transport of tiny objects using electrohydrodynamic convection (EHC) rolls in liquid crystals. Colloidal chains act as microtraction engines, enabling directed motion and cargo transport.

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Area of Science:

Soft matter physics
Colloidal science
Microfluidics

Background:

Tunable transport of microscopic objects is crucial for applications like drug delivery and lab-on-a-chip devices.
Existing methods often lack precise control over particle movement in fluid systems.

Purpose of the Study:

To investigate the directed motion of colloidal particles and chains within a nematic liquid crystal matrix.
To explore the potential of using these systems as microtransport devices.

Main Methods:

Utilizing electrohydrodynamic convection (EHC) rolls to generate fluid flow patterns.
Observing the behavior of single colloidal particles and self-assembled colloidal chains in the EHC flow.
Analyzing particle motion based on asymmetric molecular orientation distortions.

Main Results:

Single colloidal particles exhibit a hopping motion between EHC rolls.
Colloidal chains display a caterpillar-like motion perpendicular to the EHC roll axes.
Colloidal chains effectively function as microtraction engines for transporting microcargo.

Conclusions:

Electrohydrodynamic convection in liquid crystals provides a mechanism for controlled microparticle transport.
Colloidal chains can be engineered as efficient micro-robots for targeted cargo delivery.
This approach offers a novel strategy for micro-manipulation in fluidic environments.