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Updated: Apr 23, 2026

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Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction

Zhisen Zhang1, Zhaohu Lin1, Zheng Zhou1

  • 1Pharmaceutical Research and Early Development, Medicinal Chemistry, Discovery Technology, Molecular Design and Chemical Biology, Discovery Oncology, Roche Innovation Center Shanghai , Building 5, Lane 720, Cai Lun Road, Shanghai 201203, China ; Pharmaceutical Research and Early Development, Medicinal Chemistry, Discovery Technology, Molecular Design and Chemical Biology, Discovery Oncology, Roche Innovation Center Shanghai , Building 5, Lane 720, Cai Lun Road, Shanghai 201203, China.

ACS Medicinal Chemistry Letters
|September 16, 2014
PubMed
Summary

Researchers designed potent cyclic peptide inhibitors targeting the YAP-TEAD protein-protein interaction crucial for cancer growth. These novel inhibitors show significant promise for treating YAP-involved cancers.

Keywords:
Peptide inhibitorTEADYAPconformational constraintprotein−protein interaction

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