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Structure-Based Design of a Potent, Selective, and Brain Penetrating PDE2 Inhibitor with Demonstrated Target

Peter Buijnsters1, Meri De Angelis2, Xavier Langlois1

  • 1Neuroscience Medicinal Chemistry, Janssen Research & Development, a Division of Janssen Pharmaceutica NV , Turnhoutseweg 30, 2340 Beerse, Belgium.

ACS Medicinal Chemistry Letters
|September 16, 2014
PubMed

Keywords:
PDE2 inhibitor[1,2,4]triazolo[4,3-a]quinoxalinesphosphodiesterase 2target engagement

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