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Updated: Apr 23, 2026
Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
Published on: December 7, 2011
Bone mass and hormone analysis in patients with spinal cord injury: evidence for a gonadal axis disruption
Alexandra Passos Gaspar1, Cynthia M A Brandão, Marise Lazaretti-Castro
1Division of Endocrinology (A.P.G., C.M.A.B., M.L.-C.), Universidade Federal de São Paulo, São Paulo 04021-001, Brazil; and Associação de Assistência à Criança Deficiente (A.P.G.), São Paulo 04027-000, Brazil.
Context:
Bone loss is a constant finding in patients with spinal cord injury (SCI).
Objective:
We sought to evaluate potential modifiable factors that could lead to bone loss in complete motor paraplegia by examining gonadal axis hormones, vitamin D status, and bone markers.
Design:
This is a cross sectional.
Setting:
It includes SCI Outpatient.
Patients And Other Participants:
Twenty-nine chronic male patients with SCI were compared with 17 age-matched, able-bodied men.
Main Outcome Measure:
The bone mineral density (BMD) of lower limbs and lumbar spine were measured using dual x-ray absorptiometry. Parathormone, 25-hydroxyvitamin D [25(OH)D], collagen type I C-terminal telopeptide (CTX), and sexual hormone were measured.
Results:
Patients with SCI had lower BMD at the inferior limbs sites. CTX showed an inverse relationship with the time since injury. Patients had lower free T levels (SCI, 12.00 ± 2.91 vs controls, 19.51 ± 5.72; P ≤ .001), and the majority (72%) had normal/low levels of gonadotropins. Low T, however, was not related to low bone mass in patients with SCI. In the controls, the 25(OH)D level was positively correlated with the T and with the lumbar spine BMD, but these correlations were not observed in the SCI.
Conclusions:
Impairment of testicular function after SCI was indicated by the low levels of T and the loss of correlation between T and 25(OH)D levels; this correlation was present in the able-bodied controls. Inappropriate levels of gonadotropins were identified in most patients, featuring a hypogonadotropic hypogonadism and suggesting a disruption of the pituitary-gonadal axis. T concentrations might not be an effective target for bone loss therapy.
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