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Updated: Apr 23, 2026
10:10
Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
Published on: October 4, 2018
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Volume transmission signalling via astrocytes.
Hajime Hirase1, Youichi Iwai2, Norio Takata3
1Laboratory for Neuron-Glia Circuitry, RIKEN Brain Science Institute, Wako, Saitama, Japan Saitama University Brain Science Institute, Saitama, Saitama, Japan hirase@brain.riken.jp.
Summary
Astrocytes influence brain plasticity by releasing gliotransmitters. Activating astrocyte G-protein coupled receptors (GPCRs) with neuromodulators may switch neural networks to a plastic state, impacting attention.
Area of Science:
- Neuroscience
- Astrocyte Biology
- Synaptic Plasticity
Background:
- Astrocytes modulate synaptic function through gliotransmission and synapse ensheathment.
- Astrocyte G-protein coupled receptor (GPCR) activation elevates intracellular calcium, linked to gliotransmission.
Purpose of the Study:
- To review the role of astrocytic GPCR activation in promoting synaptic plasticity.
- To explore volume transmission of neuromodulators as a mechanism for activating astrocytic GPCRs.
Main Methods:
- Literature review of astrocyte signaling and synaptic plasticity.
- Discussion of GPCRs, calcium signaling, and gliotransmission in astrocytes.
Main Results:
- Astrocytic GPCR activation can trigger synaptic plasticity via gliotransmitter release.
- Volume transmission of neuromodulators may activate astrocytic GPCRs.
Conclusions:
- Astrocytic GPCRs are potential regulators of synaptic plasticity.
- Neuromodulator-induced astrocyte activation could facilitate network plasticity during attention.
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