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Feedback Inhibition

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!

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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.

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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.

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Related Experiment Video

Updated: Apr 23, 2026

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity

Analysis of Circadian Photoresponses in Drosophila Using Locomotor Activity

The authors reply

Stephen M Pastores¹, Henry E Fessler, Janice L Zimmerman

¹Department of Anesthesiology and Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD Critical Care Medicine, Houston Methodist Hospital, Houston, TX Center for Adult Critical Care, Division of Pulmonary and Critical Care Medicine, Virginia Commonwealth University Health System, Medical College of Virginia Hospitals and Physicians, Richmond, VA Division of Pulmonary, Critical Care, and Sleep Medicine, University of Mississippi Medical Center, Jackson, MS Department of Critical Care Medicine, Mayo Clinic Arizona, Phoenix, AZ Division of Pulmonary, Allergy and Critical Care, Emory University School of Medicine, Atlanta, GA; on behalf of the Critical Care Societies Collaborative Task Force on Critical Care Educational Pathways in Internal Medicine.

Critical Care Medicine

|September 17, 2014

Summary

No abstract available in PubMed .

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