Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Trials01:16

Clinical Trials

8.5K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
8.5K
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

625
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
625
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.7K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.7K
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

413
Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...
413
Elements Crucial for Effective Psychotherapy01:25

Elements Crucial for Effective Psychotherapy

434
Research has highlighted several critical factors that influence the effectiveness of psychotherapy, such as the therapeutic alliance, the therapist, and the client.
The Therapeutic Alliance
The therapeutic alliance refers to the relationship between the therapist and the client. The alliance strengthens when the therapist and the client engage in a nurturing, supportive, trusting, empathetic, and respectful relationship, improving therapeutic outcomes. Therapists must monitor this relationship...
434
Bioequivalence of Drugs: Drugs with Multiple Indications01:09

Bioequivalence of Drugs: Drugs with Multiple Indications

230
The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each...
230

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reporting Interest-Holder Engagement in Practice Guidelines: The RIGHT-MuSE Checklist.

Annals of internal medicine·2026
Same author

Assessing the trustworthiness of health guidelines recommendations: the transparent, rigorous, useable, standardized, and trustworthy guide (TRUSTGUIDES) tools development.

Journal of clinical epidemiology·2026
Same author

Back in Circulation: A Review of the Implementation of Thoracoabdominal Normothermic Regional Perfusion in Donation After Circulatory Death in Lung Transplantation.

Transplant international : official journal of the European Society for Organ Transplantation·2026
Same author

The American Association for Thoracic Surgery (AATS) 2026 Expert Consensus Document: Guidelines for donor/recipient size-matching in lung transplantation.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Abrogation of Oncogenic RAS Signaling by a RAS(ON) Inhibitor Doublet Primes Immune-Refractory KRASG12C-Mutant NSCLC for Immune Checkpoint Blockade.

Cancer discovery·2026
Same author

Clinical features, management, and outcomes of right heart thrombi: a retrospective cohort study.

Thrombosis research·2025
Same journal

Parent's hesitance about HPV Vaccine: Using the CASE approach to address their concerns.

Minnesota medicine·2021
Same journal

Vaping, lung injury, and mental health Minnesota 2018-2019.

Minnesota medicine·2021
Same journal

Characteristics of clinical extrapulmonary nontuberculous mycobacteria isolates in Minnesota, 2013-2017.

Minnesota medicine·2020
Same journal

Challenges for younger adults with diabetes.

Minnesota medicine·2020
Same journal

Telemedicine in Minnesota: A look at how four specialties are using it.

Minnesota medicine·2019
Same journal

The Doctor Will See You On Screen: Telemedicine offers convenient access to care, cost savings and the same quality as in-person visits-sometimes.

Minnesota medicine·2019
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.0K

Comparative effectiveness research in clinical practice.

William F Lawrence, Stephanie Chang, Robert L Kane

    Minnesota Medicine
    |September 18, 2014
    PubMed
    Summary
    This summary is machine-generated.

    The Agency for Healthcare Research and Quality (AHRQ) funds systematic reviews on comparative effectiveness research to guide treatment decisions. These unbiased reviews offer crucial data on treatment risks and benefits for patients and clinicians.

    More Related Videos

    Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
    14:32

    Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

    Published on: February 16, 2011

    26.2K
    A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
    14:43

    A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

    Published on: January 12, 2018

    14.4K

    Related Experiment Videos

    Last Updated: Apr 23, 2026

    E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
    06:28

    E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

    Published on: August 1, 2019

    8.0K
    Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care
    14:32

    Using Visual and Narrative Methods to Achieve Fair Process in Clinical Care

    Published on: February 16, 2011

    26.2K
    A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
    14:43

    A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

    Published on: January 12, 2018

    14.4K

    Area of Science:

    • Health Services Research
    • Evidence-Based Medicine

    Background:

    • The Agency for Healthcare Research and Quality (AHRQ) has a 10-year federal mandate to fund systematic reviews.
    • Comparative effectiveness research (CER) is crucial for informing healthcare decisions.

    Purpose of the Study:

    • To describe the concept and application of comparative effectiveness research.
    • To highlight the utility of CER for clinical practice.
    • To acknowledge contributions from the Minnesota Evidence-based Practice Center.

    Main Methods:

    • Systematic reviews funded by AHRQ.
    • Analysis of treatment alternatives' effectiveness and risks.

    Main Results:

    • AHRQ has supported reviews in 17 diverse areas.
    • These reviews serve as reliable, unbiased information sources.

    Conclusions:

    • Comparative effectiveness research provides essential information for patients and clinicians.
    • Physicians can integrate CER findings into their clinical practice for improved patient outcomes.