Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Type I Diabetes I: Introduction

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1...

Carbohydrate Metabolism

Carbohydrate Metabolism

Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...

Diabetes Mellitus: Overview and Type I Subtype

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...

Type I Diabetes II: Pathophysiology

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...

Type II Diabetes I: Introduction

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...

Diabetes Mellitus: Type 2 and Gestational

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Injectable semaglutide and reductions in HbA1c and weight in the real world in people switched from alternative glucagon-like peptide-1 receptor agonists.

Diabetes, obesity & metabolism·2022

Same author

The competitive athlete with type 1 diabetes.

Diabetologia·2020

Same author

Exercise and physical activity in patients with type 1 diabetes - Authors' reply.

The lancet. Diabetes & endocrinology·2017

Same author

Exercise management in type 1 diabetes: a consensus statement.

The lancet. Diabetes & endocrinology·2017

Same author

Diabetes management for intense exercise.

Current opinion in endocrinology, diabetes, and obesity·2009

Same author

Treatment of HNF1-alpha MODY with the DPP-4 inhibitor Sitagliptin(1).

Diabetic medicine : a journal of the British Diabetic Association·2009

Search research articles

Related Experiment Video

Updated: Apr 23, 2026

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

Exercise for people with type 1 diabetes.

¹Royal Berkshire NHS Foundation Trust Centre for Diabetes and Endocrinology, Royal Berkshire Hospital, Reading, UK.

Medicine and Sport Science

|September 18, 2014

Summary

This summary is machine-generated.

Exercise significantly impacts blood glucose levels in people with type 1 diabetes (T1DM), causing hypo- and hyperglycemia. Understanding these effects and utilizing advanced insulin pump and glucose monitoring technologies can help manage blood sugar during physical activity.

More Related Videos

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

Related Experiment Videos

Last Updated: Apr 23, 2026

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Author Spotlight: Advancing Diabetes Research with Static Exercise Training in Mice

Published on: March 29, 2024

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

Area of Science:

Endocrinology
Exercise Physiology
Metabolic Disorders

Background:

Exercise in type 1 diabetes (T1DM) causes significant blood glucose fluctuations, including hypoglycemia and hyperglycemia.
Exercise type, intensity, and duration differentially affect glycemic control and endocrine responses in T1DM.
Impaired exercise performance is a concern for individuals with T1DM.

Purpose of the Study:

To review current knowledge on exercise-induced glycemic changes in T1DM.
To discuss management strategies for maintaining euglycemia during exercise in T1DM.
To highlight the role of emerging technologies in managing T1DM during exercise.

Main Methods:

Literature review of studies on exercise and T1DM.
Analysis of factors influencing glycemic response to exercise.
Evaluation of technological advancements in diabetes management.

Main Results:

Exercise elicits variable glycemic responses (hypo-/hyperglycemia) in T1DM.
Different exercise characteristics lead to distinct endocrine and glycemic outcomes.
Recent advancements improve understanding and management of exercise in T1DM.

Conclusions:

Effective management strategies are crucial for euglycemia during exercise in T1DM.
Technological innovations, including insulin pumps and continuous glucose monitoring, offer promising solutions for T1DM management during physical activity.