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Fabrication of multilayer-PDMS based microfluidic device for bio-particles concentration detection
Marianah Masrie1, Burhanuddin Yeop Majlis2, Jumril Yunas2
1Institute of Microengineering and Nanoelectronics (IMEN), Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia Faculty of Electrical Engineering, Universiti Teknologi Mara Shah Alam, Selangor, Malaysia.
Bio-Medical Materials and Engineering
|September 18, 2014
Summary
A new multilayer-Polydimethylsiloxane (PDMS) fabrication method precisely controls microfluidic device thickness for enhanced bio-particle detection in Lab-on-chip systems. This technique optimizes light path length for improved optical detection sensitivity.
Area of Science:
- Microfluidics
- Biotechnology
- Optical Engineering
Background:
- Standard soft lithography for Polydimethylsiloxane (PDMS) microfluidic devices results in inconsistent layer thickness.
- Precise layer thickness is crucial for microfluidic devices integrated with optical transducers, affecting light path length and detection sensitivity.
Purpose of the Study:
- To develop and present a multilayer-PDMS fabrication process for creating microfluidic devices with specific, fixed layer thicknesses.
- To enhance bio-particle concentration detection in Lab-on-chip systems by optimizing optical detection through controlled light path lengths.
Main Methods:
- Utilized standard photolithography and soft lithography techniques.
- Developed a novel multilayer-PDMS fabrication approach to achieve precise micron-level thickness control.
- Integrated the fabricated microfluidic device with an optical transducer for signal response analysis.
- Characterized the fabrication process using Scanning Electron Microscopy (SEM).
Main Results:
- The multilayer-PDMS method successfully produced microfluidic layers with specific and fixed thicknesses.
- The proposed method demonstrated excellent bonding between the multilayer-PDMS layer and the biocompatible microfluidic channel.
- Optical signal responses from the multilayer-PDMS device showed no significant difference in light propagation dispersion compared to conventional methods.
Conclusions:
- The multilayer-PDMS fabrication technique offers a viable solution for creating microfluidic devices with controlled layer thickness.
- This method is suitable for Lab-on-chip systems requiring precise optical path lengths for sensitive bio-particle detection.
- The enhanced bonding and controlled thickness contribute to improved performance in optical detection applications.
