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Layer-by-layer Synthesis and Transfer of Freestanding Conjugated Microporous Polymer Nanomembranes

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pH-responsive mesoporous silica nanocarriers based on layer-by-layer self-assembly.

Hong-Yu Zhang¹, Yan-Fang Sun¹, Yu-Long Sun¹

¹State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.

Bio-Medical Materials and Engineering

|September 18, 2014

Summary

Researchers developed pH-sensitive nanocarriers using carboxyl-modified mesoporous silica nanoparticles coated with polycations and polyanions. The S5-B/PAA coating demonstrated high drug loading and significant pH-responsive release, showing promise for targeted drug delivery.

Keywords:

Layer-by-layer mesoporous silica nanoparticles pH-responsivity poly (glycerol methacrylate)

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Area of Science:

Materials Science
Nanotechnology
Drug Delivery

Background:

pH-sensitive drug delivery systems are crucial for targeted therapeutic release.
Layer-by-layer self-assembly nanocarriers offer tunable properties based on pH-induced changes.
Mesoporous silica nanoparticles (MSNs) are effective reservoirs for drug encapsulation.

Purpose of the Study:

To develop novel pH-sensitive nanocarriers using carboxyl-modified mesoporous silica nanoparticles (MSNs-COOH).
To investigate the drug loading and release characteristics of nanocarriers coated with different polycation/polyanion layers.
To evaluate the potential of these nanocarriers for targeted drug delivery applications.

Main Methods:

MSNs-COOH were synthesized and loaded with Rhodamine B (RhB) as a model drug.
Layer-by-layer self-assembly was used to coat MSNs-COOH with polycations (L-B, S5-B, S5-E) and polyanion (PAA).
Characterization included transmission electron microscopy, FTIR, TGA, and dynamic light scattering; drug release was studied at different pH values.

Main Results:

The S5-B/PAA coated nanocarriers exhibited the highest loading capacity (10.1%) and entrapment efficiency (44.4%) for RhB.
Significant pH-responsive release of RhB was observed, with approximately 90% release at pH 2.0 and 35% at pH 7.4.
The nanocarriers demonstrated structural stability and controlled permeability influenced by pH.

Conclusions:

The developed MSNs-COOH coated with S5-B/PAA represent a promising pH-sensitive nanocarrier system.
The observed pH-responsive drug release profile is suitable for targeted delivery applications.
This system holds potential for enhancing the efficacy and safety of drug delivery therapies.