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Published on: September 2, 2025
A non-invasive navigation system for retargeting gastroscopic lesions
Jiquan Liu1, Bin Wang1, Weiling Hu2
1College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China Key Laboratory for Biomedical Engineering, Ministry of Education, Zhejiang University, Hangzhou 310027, China.
A new computer aided endoscopic navigation (CAEN) system offers a non-invasive alternative to traditional endoscopic tattooing for marking gastric lesions. This navigation system provides accurate lesion targeting, improving surveillance and reducing procedural time.
Area of Science:
- Gastroenterology
- Medical Devices
- Surgical Navigation
Background:
- Traditional endoscopic tattooing for premalignant gastric lesion surveillance is invasive, may lack durability, and carries risks.
- Existing methods for marking biopsy sites during endoscopic surveillance present several disadvantages, including invasiveness and potential for diffusion.
Purpose of the Study:
- To develop and evaluate a computer aided endoscopic navigation (CAEN) system for non-invasive biopsy procedures.
- To provide a more accurate and efficient method for tracking gastric lesions compared to traditional endoscopic tattooing.
Main Methods:
- Development of a novel six degree of freedom (6-DOF) tracking endoscope device integrated with a computer simulated workstation.
- Utilizing the CAEN system to record lesion locations touched by the endoscope tip for subsequent guidance during follow-up procedures.
Main Results:
- Clinical experiments demonstrated high accuracy in lesion localization, with a mean accuracy of 7.5 mm (P-value = 0.023).
- The CAEN system showed specific accuracies: angularis (5.2 ± 2.8 mm), antral lesser curvature (7.2 ± 2.0 mm), antral greater curvature (6.3 ± 3.1 mm), antral posterior wall (8.2 ± 1.6 mm), and antral anterior wall (7.9 ± 1.3 mm).
- The CAEN system significantly reduced procedural time compared to endoscopic tattooing.
Conclusions:
- The developed CAEN system is a viable, non-invasive alternative for endoscopic surveillance of gastric lesions.
- The system's accuracy and efficiency make it suitable for clinical practice, offering an improvement over traditional tattooing methods.

