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Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
Interplay between the immune system and adipose tissue in obesity
Mark A Exley1, Laura Hand2, Donal O'Shea2
1Department of MedicineBrigham and Women's Hospital, Thorn Bldg, 1405, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USAFaculty of Medical and Human SciencesManchester Collaborative Centre for Inflammation Research (MCCIR), University of Manchester, 46 Grafton Street, CTF Building Room 2.14b, Manchester M13 9NT, UKDepartment of EndocrinologySt. Vincent's University Hospital, University College Dublin, Dublin, IrelandDepartment of MedicineBrigham and Women's Hospital, Smith Building, Harvard Medical School, One Jimmy Fund Way, Boston, Massachusetts 02115, USA Department of MedicineBrigham and Women's Hospital, Thorn Bldg, 1405, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USAFaculty of Medical and Human SciencesManchester Collaborative Centre for Inflammation Research (MCCIR), University of Manchester, 46 Grafton Street, CTF Building Room 2.14b, Manchester M13 9NT, UKDepartment of EndocrinologySt. Vincent's University Hospital, University College Dublin, Dublin, IrelandDepartment of MedicineBrigham and Women's Hospital, Smith Building, Harvard Medical School, One Jimmy Fund Way, Boston, Massachusetts 02115, USA mexley@partners.org.
Obesity causes white adipose tissue (WAT) inflammation, impacting metabolic health. Understanding WAT
Area of Science:
- Immunology
- Endocrinology
- Metabolic Disease Research
Background:
- Obesity is a primary risk factor for metabolic diseases.
- White adipose tissue (WAT) inflammation is a key pathological driver.
- WAT functions as an endocrine organ, secreting immunoregulatory adipokines.
Purpose of the Study:
- To explore the role of adipose tissue leukocytes in obesity-associated inflammation.
- To understand the immune cell repertoire within WAT.
- To highlight potential anti-inflammatory therapies for obesity-related pathology.
Main Methods:
- Review of current literature in immuno-metabolism.
- Analysis of the unique immune cell populations in WAT.
- Discussion of the interplay between adipose tissue immunity and metabolic dysfunction.
Main Results:
- WAT harbors a distinct immune cell population, including specific macrophages and T cells.
- Disruption of leukocyte homeostasis in WAT contributes to inflammation.
- Adipokines produced by WAT possess immunoregulatory functions.
Conclusions:
- Adipose tissue immunity is crucial for understanding metabolic disorders.
- Targeting WAT leukocytes may offer novel therapeutic strategies.
- Further research into immuno-metabolism is essential for combating obesity.
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