Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optimising DNA origami assembly by reducing off-target interactions.

Nature communications·2026

Same author

Selection and Characterization of SARS-CoV-2 Spike Binding Clickmers.

Chembiochem : a European journal of chemical biology·2026

Same author

A Multi-Faceted Binding Assessment of Aptamers Targeting the SARS-CoV-2 Spike Protein.

International journal of molecular sciences·2024

Same author

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower.

Nature nanotechnology·2023

Same author

Reconfigurable Nanopolygons Made of DNA Catenanes.

Bioconjugate chemistry·2023

Same author

Spin Labeling of Long RNAs Via Click Reaction and Enzymatic Ligation.

Methods in molecular biology (Clifton, N.J.)·2022

Search research articles

Related Experiment Video

Updated: Apr 23, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Interlocked DNA nanostructures controlled by a reversible logic circuit.

Tao Li¹, Finn Lohmann¹, Michael Famulok²

¹Chemical Biology and Medicinal Chemistry Unit, Life and Medical Science (LIMES) Institute, University of Bonn, 53121 Bonn, Germany.

Nature Communications

|September 18, 2014

Summary

Researchers developed a reversible logic circuit using DNA nanostructures. This DNA nanorobot system integrates logic computing and nanomechanics for potential use in biological systems.

More Related Videos

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Related Experiment Videos

Last Updated: Apr 23, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Area of Science:

Biotechnology
Nanotechnology
Molecular Biology

Background:

DNA nanostructures are promising for logic computing and nanomechanics.
Integrating these fields can lead to intelligent DNA nanorobots.

Purpose of the Study:

To create a reversible logic circuit using DNA nanostructures.
To demonstrate Boolean operations with DNA nanostructures for nanorobotics.

Main Methods:

Programmable assembly of a double-stranded DNA [3]pseudocatenane scaffold.
Utilizing a bimolecular i-motif and a G-quadruplex as functional motifs.
Triggering structural changes via pH and release oligodeoxynucleotides for Boolean logic.

Main Results:

A reversible logic circuit based on DNA nanostructures was successfully built.
The circuit functions as tandem YES and AND gates.
Structural changes were converted into Boolean operations using fluorescence labeling.

Conclusions:

The developed DNA nanostructure functions as a reversible logic circuit.
This system integrates logic computing and nanomechanics.
It provides a foundation for future DNA nanorobots to manipulate biological cascade reactions.