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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
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Molecular biology, pathogenesis and pathology of mumps virus

Steven Rubin1, Michael Eckhaus, Linda J Rennick

  • 1Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.

The Journal of Pathology
|September 18, 2014
PubMed

Insights

Mumps virus (MuV) causes painful inflammation and can infect the central nervous system (CNS). Renewed interest in MuV pathogenesis and disease models is driven by recent outbreaks.

Area of Science:

  • Virology
  • Immunology
  • Neurology

Background:

  • Mumps is caused by the mumps virus (MuV), an enveloped RNA virus from the Paramyxoviridae family.
  • Mumps presents with inflammatory symptoms like parotitis and orchitis.
  • MuV is neurotropic, frequently causing central nervous system (CNS) infection, and was a leading cause of viral meningitis and encephalitis before vaccination.

Purpose of the Study:

  • To review the current understanding of mumps virus (MuV).
  • To explore MuV pathogenesis and clinical outcomes.
  • To highlight the need for better disease models due to resurgent mumps cases.

Main Methods:

  • This is a review article, synthesizing existing research on mumps virus.
  • Literature search on mumps virus, its pathogenesis, and clinical manifestations.
  • Analysis of recent mumps outbreaks and their implications.

Main Results:

  • Mumps virus (MuV) infection is associated with significant inflammatory conditions and neurological complications.
  • Despite widespread vaccination, mumps resurgence is occurring globally.
  • Existing knowledge on MuV pathogenesis and clinical outcomes requires updating.

Conclusions:

  • Further research into mumps virus (MuV) pathogenesis is crucial.
  • Development of clinically relevant disease models is needed to combat mumps resurgence.
  • Understanding MuV is essential for public health, especially given recent outbreaks.
Keywords:
mumpsmumps virusneurovirulencepathogenesisvaccine

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