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Updated: Apr 23, 2026
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
[Relationship between serum 25-hydroxyvitamin D and bone mineral density in children under 7 years old]
Fei Xiong1, Fan Yang, Su-Fei Yang
1Department of Pediatrics, West China Second University Hospital, Chengdu 610041, China. xiongfei7922.student@sina.com.
Objective:
To evaluate the endogenous vitamin D level and its correlation with bone mineral density (BMD) in children under 7 years old.
Methods:
Totally 6 838 children who visited the Growth and Development Clinic due to "growth retardation, night terrors, hyperhidrosis, and dysphoria" were enrolled in the study. Serum 25-hydroxyvitamin D [25(OH)D] level was measured by chemiluminescence, whereas individual BMD was measured by quantitative ultrasound.
Results:
Among all subjects, serum 25(OH)D level was 34 ± 14 ng/mL, and the Z value of BMD was -0.49 ± 0.54. With increasing age, serum 25(OH)D level and BMD decreased gradually (P<0.01), and the detection rates for vitamin D deficiency and low BMD increased gradually (P<0.01). Compared with those with sufficient vitamin D, children with vitamin D deficiency had a significantly lower BMD (P<0.01) and a significantly higher detection rate for low BMD (P<0.01). 25-(OH)D level showed a positive linear correlation with BMD in children with vitamin D deficiency (P<0.01).
Conclusions:
Preschool and school-age children have severer vitamin D deficiency than infants. Vitamin D level may be correlated with BMD within a certain range.
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