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[Diagnostic value of high mobility group box 1 for acute appendicitis in children]

Jian-Fen Hu1, Jiang-Yan Wu, Lin Zhang

  • 1Department of Emergency, Hunan Children's Hospital, Changsha 410007, China. hujianfenbaobao@sina.com.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|September 18, 2014
PubMed

Insights

High mobility group box 1 (HMGB1) shows potential in diagnosing pediatric acute appendicitis. Elevated HMGB1 levels were observed in children with appendicitis, aiding in diagnosis.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Diagnostic Markers

Context:

  • Acute appendicitis is a common surgical emergency in children.
  • Accurate and timely diagnosis is crucial to prevent complications.
  • Current diagnostic methods can have limitations.

Purpose:

  • To investigate the diagnostic utility of serum High Mobility Group Box 1 (HMGB1) levels in pediatric acute appendicitis.
  • To compare HMGB1 levels between children with and without appendicitis.

Summary:

  • Serum HMGB1 levels and white blood cell (WBC) counts were significantly higher in children with appendicitis compared to healthy controls.
  • The appendicitis group exhibited higher HMGB1 levels (median 32.9 ng/mL) than the non-appendicitis group (median 22.0 ng/mL).
  • Serum HMGB1 demonstrated a sensitivity of 71.4% and specificity of 82.9% for diagnosing acute appendicitis at a cutoff of 28.0 ng/mL.

Impact:

  • HMGB1 may serve as a valuable biomarker for the diagnosis of pediatric acute appendicitis.
  • This finding could lead to improved diagnostic strategies and patient outcomes.
  • Further research can explore HMGB1's role in differentiating appendicitis severity.
Abstract

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