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The role of hemostasis in infective endocarditis

Emanuele Durante-Mangoni1, Rosa Molaro, Domenico Iossa

  • 1Internal Medicine, University of Naples S.U.N., Monaldi Hospital, Via L. Bianchi snc, 80131, Naples, Italy, emanuele.durante@unina2.it.

Current Infectious Disease Reports
|September 19, 2014
PubMed

Insights

Infective endocarditis (IE) involves the heart

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Infectious Diseases

Background:

  • Infective endocarditis (IE) is a complex thromboinflammatory condition affecting the heart's inner lining.
  • Its pathophysiology is intricately linked to the interaction between pathogens and the hemostasis system.

Purpose of the Study:

  • To systematically review and appraise existing experimental and clinical data on the role of hemostasis in IE.
  • To explore the interplay between microorganisms, hemostasis modifiers, and IE development.
  • To propose a hypothesis regarding thrombophilia as a potential trigger for IE.

Main Methods:

  • Comprehensive review of experimental and clinical studies.
  • Analysis of the dual role of platelets in IE pathogenesis.
  • Examination of microbial interactions with the hemostasis system and nonspecific changes during sepsis.

Main Results:

  • Hemostasis plays a critical, multifaceted role in IE susceptibility, progression, and treatment.
  • Platelets exhibit a dual function in the context of IE.
  • Microbial interactions significantly influence the hemostasis system.

Conclusions:

  • The hemostasis system is a crucial factor in infective endocarditis.
  • Thrombophilia is hypothesized as a potential trigger for IE.
  • Pharmacological modulation of hemostasis presents a promising, yet largely unexplored, therapeutic avenue for IE.

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