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Pathogenesis of heart failure
1University of Chicago Pritzker School of Medicine, Chicago, Illinois.
Insights
Myocardial remodeling involves cardiac muscle, microcirculation, and extracellular matrix. This review explores pathologic hypertrophy and its role in heart failure.
Area of Science:
- Cardiovascular Biology
- Cardiac Pathophysiology
Background:
- The myocardium comprises cardiac muscle cells, microcirculation, and extracellular matrix.
- Myocardial remodeling, affecting all compartments, can be adaptive or pathologic.
Purpose of the Study:
- To review the process of myocardial remodeling.
- To discuss the pathogenetic features of pathologic hypertrophy leading to heart failure.
Main Methods:
- Literature review of existing research on myocardial remodeling and heart failure.
Main Results:
- Pathologic hypertrophy involves complex changes in cardiac muscle, vasculature, and collagen structure.
- Understanding these changes is crucial for identifying therapeutic targets.
Conclusions:
- Myocardial remodeling is a key factor in the development of heart failure.
- Further research into the pathogenetic mechanisms of hypertrophy is warranted.
Abstract:
The myocardium consists of three compartments: cardiac muscle cells; a nutritive microcirculation; and an extracellular matrix composed largely of fibrillar collagen. The hypertrophic remodeling of the myocardium, which involves each of these compartments, can be adaptive or pathologic. This article reviews the remodeling process and the current state of our knowledge regarding the pathogenetic features of pathologic hypertrophy with heart failure.