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Updated: Apr 23, 2026

Creating Rapid Oxygen Oscillations in Microbial Single-cell Growth Analysis using a Microfluidic Double-layer Device
Published on: July 18, 2025
Bio-inspired enol-degradation for multipurpose oxygen sensing.
Yu-Mo Zhang1, Xiaojun Wang, Wen Li
1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, Jilin 130012, P.R. China. seanzhang@jlu.edu.cn liminjie@jlu.edu.cn.
A novel dual-mode oxygen sensor was developed, inspired by luciferin degradation. This sensor offers instant fluorescence detection and adjustable color fading for food freshness indication.
Area of Science:
- Chemical Sensors
- Biochemical Assays
- Materials Science
Background:
- Luciferin degradation is a known biochemical process.
- Oxygen sensing is crucial for various applications.
- Dual-mode sensors offer enhanced analytical capabilities.
Purpose of the Study:
- To design and synthesize a novel dual-mode oxygen sensor.
- To investigate its application as an instant oxygen probe.
- To evaluate its utility as a food freshness indicator.
Main Methods:
- Synthesis of a novel sensor molecule inspired by luciferin enol-degradation.
- Characterization of the sensor's optical properties (color and fluorescence).
- Testing the sensor's response to oxygen and its color fading kinetics.
Main Results:
- The sensor exhibits oppositely changed color and fluorescence upon oxygen interaction.
- It functions as a highly selective, instant "fluorescence on" oxygen probe.
- The sensor demonstrates time-adjustable color fading for freshness monitoring.
Conclusions:
- A versatile dual-mode oxygen sensor has been successfully developed.
- The sensor provides a rapid and selective method for oxygen detection.
- Its tunable color-fading property enables practical food freshness assessment.
Related Concept Videos
Microbial Biosensors
Oxygen Requirements and Growth Patterns
Amperometry: Overview
Reactivity of Enols

