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Recurrent linezolid-resistant Enterococcus faecalis infection in a patient with pneumonia

Zhi-jian Yu1, Zhong Chen1, Hang Cheng1

  • 1Department of Infectious Diseases and Shenzhen Key Laboratory for Endogenous Infection, The Affiliated Shenzhen Nanshan Hospital, Guangdong Medical College, No. 89, Taoyuan Road, Nanshan District, Shenzhen 518052, China.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|September 20, 2014
PubMed
Abstract

Insights

Persistent colonization by linezolid-resistant Enterococcus faecalis can occur in patients, leading to recurrent pneumonia. This study analyzed the characteristics of these resistant strains in a clinical setting.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Linezolid resistance in Enterococcus is known in mice but poorly understood in human patients.
  • Recurrent pneumonia cases raise suspicion for persistent bacterial colonization.

Observation:

  • Ten Enterococcus faecalis strains were isolated from a patient with recurrent pneumonia over 10 months.
  • Pulsed-field gel electrophoresis confirmed clonal relationships among isolates.
  • Strains exhibited variable minimum inhibitory concentrations (MICs) for linezolid.

Findings:

  • Linezolid-resistant E. faecalis strains demonstrated persistent colonization in vivo.
  • Mutations in the 23S rRNA gene were identified in resistant isolates.
  • Vancomycin proved effective for treating infections caused by these strains.

Implications:

  • Persistent colonization by linezolid-resistant Enterococcus poses a significant clinical challenge.
  • Understanding colonization dynamics is crucial for managing recurrent infections.
  • Vancomycin remains a viable treatment option for such infections.
Keywords:
Antibiotic resistanceBacterial colonizationLinezolidVancomycin

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