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Alteration of lipid parameters in patients with subclinical hypothyroidism
Bashir Ahmad Laway1, Fayaz Ahmad War2, Sonaullah Shah2
1Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
Background:
Overt hypothyroidism is associated with abnormalities of lipid metabolism, but conflicting results regarding the degree of lipid changes in subclinical hypothyroidism (SCH) exist.
Objectives:
The aim of this study was to assess differences in lipid profile parameters between subjects with and without SCH in a north Indian population.
Patients And Methods:
Serum lipid parameters of 70 patients with subclinical hypothyroidism and 100 age and sex matched euthyroid controls were evaluated in a cross-sectional study.
Results:
Mean serum total cholesterol (TC), triglycerides (TG) and very low-density cholesterol (VLDL) were significantly higher in patients with SCH than controls (P < 0.05). Mean TC, TG and low-density cholesterol (LDL) concentrations were higher in patients with serum thyroid stimulating hormone (TSH) greater than 10 mU/L than those with serum TSH equal to or less than 10 mU/L, but this difference was not statistically significant. No association was found between serum high-density cholesterol (HDL-C) concentration and serum TSH level.
Conclusions:
High TC, TG and VLDL were observed in our patients with SCH.
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