Computed Tomography Cardiac Angiography Findings in Patients With Sheehan Syndrome.

Area of Science:

• Endocrinology
• Cardiology
• Radiology

Background:

• Sheehan Syndrome (SS), or postpartum pituitary necrosis, is linked to higher risks of atherosclerotic cardiovascular diseases due to factors like dyslipidemia and hormonal deficiencies.
• Understanding the specific cardiovascular risks in SS patients is crucial for effective management and prevention strategies.

Purpose of the Study:

• To evaluate the prevalence and characteristics of coronary artery atherosclerotic disease in women with Sheehan Syndrome.
• To utilize computed tomography cardiac angiography for noninvasive assessment of coronary arteries in this patient group.

Main Methods:

• An observational, cross-sectional study was conducted on 30 women diagnosed with Sheehan Syndrome.
• Participants were undergoing standard hormone replacement therapy.
• Computed tomography cardiac angiography was performed to detect and analyze coronary artery plaques.

Main Results:

• Coronary artery plaques were identified in 23.3% of the 30 Sheehan Syndrome patients studied.
• Coronary artery calcium (CAC) scoring indicated varying levels of coronary artery disease risk among participants.
• A significant positive correlation (r = 0.96, P = .01) was found between CAC scores and the percentage of arterial stenosis.

Conclusions:

• Atherosclerotic plaques are present in a notable proportion of patients with Sheehan Syndrome, underscoring their heightened susceptibility.
• These findings highlight the increased risk of cardiovascular morbidity and mortality in individuals with SS.
• Noninvasive imaging like CT angiography is valuable for assessing cardiovascular risk in Sheehan Syndrome patients.