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Updated: Apr 23, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Therapeutic advancements in multiple myeloma
Alessandro Gozzetti1, Veronica Candi1, Giulia Papini1
1Azienda Ospedaliera Universitaria Senese, Policlinico "Santa Maria alle Scotte" , Siena , Italy.
Novel agents and stem-cell transplantation have significantly improved multiple myeloma survival rates. New treatments like carfilzomib and pomalidomide offer continued hope for patients with this blood cancer.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Multiple myeloma survival rates have seen significant recent improvements.
- Novel therapeutic agents have transformed treatment paradigms.
Purpose of the Study:
- To review the impact of recent advancements on multiple myeloma survival.
- To highlight the efficacy of novel agents and treatment strategies.
Main Methods:
- Review of clinical data on novel agents for multiple myeloma.
- Analysis of treatment strategies including transplantation, consolidation, and maintenance.
- Inclusion of recently approved drugs like carfilzomib and pomalidomide.
Main Results:
- Introduction of thalidomide, bortezomib, and lenalidomide has increased complete remission and progression-free survival.
- Autologous stem-cell transplantation further enhances patient outcomes.
- Consolidation and maintenance therapies improve treatment responses.
Conclusions:
- The combination of novel agents and autologous stem-cell transplantation has led to prolonged survival in multiple myeloma.
- Emerging drugs and strategies indicate a brighter future for patients.
- Continued research and development are crucial for further improving outcomes.
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05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
07:24Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
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